SrasV1, Main, Exploration, bibRecord, 005B18

Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons

Identifieur interne : 005B18 ( Main/Exploration ); précédent : 005B17; suivant : 005B19

Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons

Auteurs : Carolina Scagnolari [Italie] ; Elisa Vicenzi [Italie] ; Francesca Bellomi [Italie] ; Maria Giuseppina Stillitano [Italie] ; Debora Pinna [Italie] ; Guido Poli [Italie] ; Massimo Clementi [Italie] ; Ferdinando Dianzani [Italie] ; Guido Antonelli [Italie]

Source :

Antiviral therapy : (London) [ 1359-6535 ] ; 2004.

RBID : Pascal:05-0076971

Descripteurs français

KwdFr :
- Animaux, Cellules Vero, Humains, Interféron de type I (génétique), Interféron de type I (pharmacologie), Interféron gamma (génétique), Interféron gamma (pharmacologie), Protéines G (génétique), Protéines G (métabolisme), Protéines de résistance aux myxovirus, Protéines recombinantes (pharmacologie), Réplication virale (), Synergie des médicaments, Virus du SRAS (), Virus du SRAS (physiologie).
MESH :
- génétique : Interféron de type I, Interféron gamma, Protéines G.
- métabolisme : Protéines G.
- pharmacologie : Interféron de type I, Interféron gamma, Protéines recombinantes.
- physiologie : Virus du SRAS.
Pascal (Inist)
- Animaux, Cellules Vero, Humains, Protéines de résistance aux myxovirus, Réplication virale, Sensibilité, Synergie des médicaments, Virus du SRAS, Virus syndrome respiratoire aigu sévère, Homme, Cytokine, Interféron.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Animals, Chlorocebus aethiops, Cytokine, Drug Synergism, GTP-Binding Proteins (genetics), GTP-Binding Proteins (metabolism), Human, Humans, Interferon, Interferon Type I (genetics), Interferon Type I (pharmacology), Interferon-gamma (genetics), Interferon-gamma (pharmacology), Myxovirus Resistance Proteins, Recombinant Proteins (pharmacology), SARS Virus (drug effects), SARS Virus (physiology), Sensitivity, Severe acute respiratory syndrome virus, Vero Cells, Virus Replication (drug effects).
MESH :
- chemical , genetics : GTP-Binding Proteins, Interferon Type I, Interferon-gamma.
- chemical , metabolism : GTP-Binding Proteins.
- chemical , pharmacology : Interferon Type I, Interferon-gamma, Recombinant Proteins.
- drug effects : SARS Virus, Virus Replication.
- physiology : SARS Virus.
- Animals, Chlorocebus aethiops, Drug Synergism, Humans, Myxovirus Resistance Proteins, Vero Cells.

Abstract

There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">There is currently an urgent need to identify effective antiviral agents that will prevent and treat severe acute respiratory syndrome coronavirus (SARS-CoV) infection. In this study, we have investigated and compared the antiviral effect of different interferons (IFNs) on SARS-CoV replication in the epithelial kidney monkey Vero cell line. The results showed that SARS-CoV grown in Vero cells is moderately sensitive to IFN-β and only weakly sensitive to IFN-a and IFN-y, in comparison to other IFN-sensitive viruses, such as those for encephalomyocarditis, vesicular stomatitis and Newcastle disease. Simultaneous incubation of Vero cells with IFN-β and IFN-y indicated that they may act synergistically against SARS-CoV replication. The IFN-induced MxA protein was detected in the IFN-treated Vero cells. The data, however, suggest that the antiviral activity of IFN against SARS-CoV virus is independent of MxA expression.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
<region><li>Latium</li>
<li>Lombardie</li>
</region>
<settlement><li>Milan</li>
<li>Rome</li>
</settlement>
</list>
<tree><country name="Italie"><region name="Latium"><name sortKey="Scagnolari, Carolina" sort="Scagnolari, Carolina" uniqKey="Scagnolari C" first="Carolina" last="Scagnolari">Carolina Scagnolari</name>
</region>
<name sortKey="Antonelli, Guido" sort="Antonelli, Guido" uniqKey="Antonelli G" first="Guido" last="Antonelli">Guido Antonelli</name>
<name sortKey="Bellomi, Francesca" sort="Bellomi, Francesca" uniqKey="Bellomi F" first="Francesca" last="Bellomi">Francesca Bellomi</name>
<name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name>
<name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name>
<name sortKey="Dianzani, Ferdinando" sort="Dianzani, Ferdinando" uniqKey="Dianzani F" first="Ferdinando" last="Dianzani">Ferdinando Dianzani</name>
<name sortKey="Pinna, Debora" sort="Pinna, Debora" uniqKey="Pinna D" first="Debora" last="Pinna">Debora Pinna</name>
<name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name>
<name sortKey="Poli, Guido" sort="Poli, Guido" uniqKey="Poli G" first="Guido" last="Poli">Guido Poli</name>
<name sortKey="Stillitano, Maria Giuseppina" sort="Stillitano, Maria Giuseppina" uniqKey="Stillitano M" first="Maria Giuseppina" last="Stillitano">Maria Giuseppina Stillitano</name>
<name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name>
</country>
</tree>
</affiliations>
</record>

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Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons

Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons

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